If you’re considering platelet-rich plasma (PRP) therapy or you’ve just had a PRP injection, you’re probably wondering what comes next. What is recovery like? When can you resume your normal routine? Don’t worry—we’ve got you covered.
PRP therapy is an incredible treatment that taps into your body’s natural healing process to repair damaged tissues and stimulate regeneration. By isolating growth factors from your own blood and injecting them into the treated area, PRP helps accelerate recovery, whether you’re looking to improve skin texture, fight hair loss, or repair a joint injury.
But like any treatment, healing takes time. In this guide, we’ll walk you through what to expect after PRP therapy, how long to rest, and when you can safely get back to your routine.
What to Expect During the Recovery Timeline
In the first 24 to 48 hours, it’s normal to experience mild side effects like redness, swelling, bruising, and tenderness at the injection site. Don’t worry; these reactions are a sign that the healing process has begun.
The body’s natural response to PRP is to increase inflammation, which helps activate stem cell regeneration and promote tissue repair. Applying cold packs as recommended and avoiding excessive movement of the treated area can help minimize discomfort during this phase.
Over the next several weeks, the injected growth factors continue working beneath the surface, supporting collagen production, cellular renewal, and tissue repair. For patients using PRP to address hair loss or skin rejuvenation, visible improvements often start to emerge within a few weeks.
The full benefits of PRP therapy can take several months to fully develop. Because PRP stimulates the body’s natural repair mechanisms, results continue to improve over time, with many patients seeing optimal outcomes three to six months after treatment.

How Long Should You Rest After PRP Injection?
Your PRP injection recovery time depends on the treated area and the purpose of your treatment. If PRP is being used for orthopedic conditions like tendon injuries, the healing process may take longer, and a more extended recovery timeline is often necessary to promote healing in the damaged tissues.
At Oviedo Med Spa, however, we specialize in aesthetic PRP treatments, such as facial rejuvenation and hair restoration, which require far less downtime. In fact, most patients can return to their regular routine within 24 hours, with only minor restrictions. While you don’t need to put your life on hold, it’s best to avoid strenuous physical activities for at least a day to reduce irritation or swelling at the injection site.
No matter what type of PRP treatment you receive, listening to your body is key. Mild side effects like swelling, bruising, or tenderness are common and should subside within a few days. If discomfort persists or worsens, it’s always a good idea to check in with your healthcare professional for personalized guidance.

PRP: Do’s and Don’ts
To ensure optimal healing and results after your PRP injection, follow these important post-treatment guidelines:
- Stay hydrated to support your body’s healing process.
- Follow your provider’s post-treatment skincare guidelines to promote healing and maximize results.
- Avoid non-steroidal anti-inflammatory drugs (NSAIDs) and certain supplements (Aspirin, Motrin, Ibuprofen, Aleve, Gingko Biloba, Flax Oil, Vitamin E, etc.) for two weeks before and three weeks after your treatment. These can interfere with the inflammatory response needed for healing.
- Use acetaminophen (Tylenol) if you experience discomfort.
- Protect the treated area from sun exposure and avoid tanning beds to prevent irritation.
- Do not wash the treated area or take a shower for at least 12 hours post-treatment.
- Refrain from touching, pressing, or rubbing the injection site for at least 24 hours.
- Avoid applying makeup, lotions, or skincare products to the treated area for at least 24 hours.
- Skip intense physical activities for at least a day to minimize irritation and swelling.
By following these simple aftercare steps, you can ensure a smooth recovery and achieve the best possible results from your PRP treatment.
Maximize Your PRP Results with Proper Aftercare
Taking care of your skin after a PRP treatment is just as important as the procedure itself. By following the right aftercare steps, you can promote healing, reduce side effects, and ensure the best possible outcome.
Remember to listen to your body—mild swelling, redness, or tenderness is normal, but if you experience prolonged discomfort, don’t hesitate to reach out to a healthcare professional.
Ready to experience the benefits of PRP treatment for skin rejuvenation or hair restoration? Schedule a consultation at Oviedo Med Spa today and let our experts guide you on your journey to refreshed, youthful skin.